Erythema Multiforme Causes & Risks

Causes

In some cases this condition can be caused by a reaction to an infection or certain medications. Often the cause is unknown.

Erythema multiforme minor is most commonly associated with:

• Herpes simplex virus—the same virus that causes cold sores

Other triggers connected with erythema multiforme major include:

• Mycoplasma infection (bacterial lung infection)
• Cocaine use
• History of radiotherapy
• Certain medications, such as:
  • Sulfonamides
  • Tetracyclines
  • Amoxicillin
  • Ampicillin
  • Nonsteroidal anti-inflammatory drugs
  • Anticonvulsants

Risk Factors

Exposure to any of the known causes increase the risk. The conditions more commonly occurs in:

• Individuals who have had it before
• Individuals with history of cold sores (orolabial herpes) or genital herpes
• Children and young adults
• Males more than females
• Individuals who are HIV positive