In some cases this condition can be caused by a reaction to an infection or certain medications. Often the cause is unknown.
Erythema multiforme minor is most commonly associated with:
- Herpes simplex virus—the same virus that causes cold sores
Other triggers connected with erythema multiforme major include:
Exposure to any of the known causes increase the risk. The conditions more commonly occurs in:
- Individuals who have had it before
- Individuals with history of cold sores (orolabial herpes) or genital herpes
- Children and young adults
- Males more than females
- Individuals who are HIV positive
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