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Anonymous (reply to Michelle King Robson)

I was very careful to say progesterone and not progestIN. Very different substances.

Like I said, unopposed estrogen has unique risks - afib, abdominal aortic aneurysm, decreased verbal fluency, and certainly uterine cancer (if you have one). The French E3N study also suggested that unopposed estradiol (without progesterone) increased breast and ovarian cancer, whereas estradiol and progesterone (not progestins) did not.

While no randomized trial has ever been conducted on estrogen with progesterone in women without a uterus, there also have never been any long term clinical trials of estradiol alone in women with hysterectomy. Unopposed estradiol increases recurrent stroke and stroke death and secondary cardiovascular prevention studies show early increases in MI and blood clots.

The points I am making AREN'T "don't take estrogen ever", they are 1. don't take estrogen WITHOUT natural progesterone 2. don't expect hormone "replacement" to protect you from age related disease. That has been disproved. True, WHI was imperfect for many reasons. But the age-based analyses were a statistical manipulation of the data to try to eke out some benefit from estrogen that obviously was not there. Statisticians will tell you that if you do enough analyses (32 or more), you will come up with a statistically significant "finding" that may or may not be true.

September 25, 2014 - 12:41pm


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