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I've been on desipramine for months. Seems to be helping. Dr is suggesting MAOI's and taking me off desipramine, he doesn't feel like it's working. My therapist, doctor and myself think it is working. Just need to tweek with something else. Thinking Effexor. My original question is - Would decreasing the disipramine (with approval from all involved) lower my heart rate and if so how long would it take to show. Thanks