Yes, I used Proactiv for a year before I begin to have hives and swollen eyes. By hives being idiopathic the emergency room put me on a strong dose of steroids. It went away then I began using it again and the hives came back and swollen, itchy eyes. I am so disappointed because I was well pleased with Proactiv clearing my face up but I have been back and forth to urgent cares and emergency rooms trying to figure out exactly what was breaking me out. I figured it out and I threw all of my products away. For some reason, over time benzoyl peroxide begins to cause and allergic reaction. Thankful for those who shared their stories helped me to identify what is happening with me.