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Hi Alextop

Yes indeed, antidepressants can cause or lessen some neurological things like restless legs syndrome or myoclonus which is the technical term for muscle twitching. Some people cannot tolerate certain meds because they cause or worsen RLS. It sounds like that's what your husband has going.

If it was definitely caused by the Prozac it should get better soon. Other things that make RLS worse are caffeine, alcohol, sometimes Benedryl, too much leg exercise right before bedtime, electrolyte imbalance such as what might come with dehydration, and other issues. Things that can help are exercise earlier in the day, a warm bath right before bed, leg massage at bedtime, and sometimes multi-mineral supplements.

This is a frustrating problem and I hope it resolves for your husband soon. I've personally had RLS for at least 20 years and finally broke down and started taking Mirapex for it about six years ago. It has really improved my quality of life.

If the legs do not improve, your husband should definitely discuss this with his health care provider.

November 8, 2010 - 7:45am

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