Hi Rebecca - That would be a good question to ask your pharmacist or doctor, but I can provide you some general information.
Cymbalta, as you know, is an antidepressant. It falls into a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). There is another type of drug used to treat depression that falls into a category known as MAO Inhibitors. MAO stands for Monoamine Oxidase, which is an enzyme responsible for metabolizing neurotransmitors such as seratonin and norepinephrine.
The prescribing information for Nucynta, which is a brand name for
tapentadol, shows that it is a narcotic pain reliever in the same class as morphine. The prescribing information is clear that this drug should not be combined with an MAO inhibitor, but there is no such warning for SSNRI's.
Please also note that Nucynta/tapentadol is a strong medication. Do not drink alcohol while you are taking this medication. Dangerous side effects or death can occur when alcohol is combined with tapentadol. Check your food and medicine labels to be sure these products do not contain alcohol. Nucynta can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Read more: http://www.drugs.com/nucynta.html