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I take 90 mg Cymbalta and 100 mg Nucynta ER. The concern with taking these two medicines concurrently is the increased risk of serotonin syndrome, or seizures independent of serotonin syndrome. The onset of serotonin syndrome is rapid, usually within 24 hours. Although the symptoms can range from mild to severe, you would likely know rather quickly if you were affected.

Be sure not to take other serotonergic medicines such as antidepressants, triptans (for migraine headaches) or tramadol. The list of serotonergic compounds is rather long and includes some OTC natural supplements and illegal street drugs. You may want to review all of the medicines, supplements, and other drugs you take (even occasionally) with a pharmacist.

January 11, 2019 - 9:30pm


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