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My part of the presentation to the FDA was on the need for menstrual cycle evaluation (MCE) and vaccination. I presented numerous studies on MCE in other arenas of women's health - including a study on the menstrual cycle and immunity - on the PuBMed.gov web site One of the concerns I had that if young women were vaccinated during the paramenstrum their chances of getting an adverse reaction would be much higher. What my colleague Cynthia Janak and I found is that histamine which is produced by amino acids in the body, is also produced by estrogen. Girls who have pre-existing allergies (not tested in the pre-trials) are also releasing more histamine. Estrogen mimickers in the environment, food, birth control pill,s, plastics, household solvents may also release histamine. And then there is the synthetic histamine in the vaccine (L-Histidine). Girls just starting to have their periods have irregular cycles and are producing estrogen until they ovulate which could be on Day 1 or Day 100. All of this adds up to high amounts of histamine in the body which is causing the immune system to attack itself causing autoimmune diseases. Right before a girl has her period her immune system becomes more compromised so she is unable to fight off the histamine. This we believe is why many of the girl's initial symptoms return during the paramenstrum (premenstrual and menstruation). It may also be a reason why the girls are not getting better. It is a bi polar effect. There are peer reviewed studies on histamine and the menstrual cycle and immunity on the menstrual cycle on the pubmed.gov site and in the FDA webinar documents. Mothers please chart when your daughters symptoms occur in relation to their menstrual cycle - if they are still having their periods. If they are not it means that ovulation is not occurring and they are producing estrogen and histamine regularly. Apologies to the author of the article for going off topic on this - but the mothers need to know this.

April 18, 2010 - 6:54pm

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