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When speaking of genetic/familial risks please include Lynch Syndrome. A recent article written by Dr Henry Lynch Sr (published 9/09) can be found at:

Sandi Pniauskas

"Following colorectal cancer, the second most frequent cancer in Lynch syndrome is endometrial carcinoma (occurs in 40%–60% of women with the mutation), followed by carcinoma of the ovary (occurs in about 12%–15% of women with the mutation). Based on their study of the evidence, Lindor and colleagues recommend endometrial sampling and transvaginal ultrasonography of the uterus beginning between age 30 and 35. They also recommend transvaginal ultrasonograpy of the ovaries beginning at the same age. We agree with these recommendations, with the caveat that the patient must be fully apprised of the screening limitations for early detection of ovarian cancer, as well as the lack of evidence of a reduction in mortality through endometrial and ovarian screening. The efficacy of prophylactic hysterectomy and bilateral salpingo-oophorectomy in women who have a Lynch syndrome–related germline mutation is supported by evidence-based findings, and this should be offered as an option for cancer prevention after a woman’s family is completed. "

September 3, 2009 - 8:07pm


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