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I have been taking Pristiq for about 6 months and it has helped tremendously with depression. I have taken everything on the market with a little help but none as good as this. However I was not told about hot flashes...after read these comments, I am thinking ah ha! It has been very confusing to me. I should be long past the hot flashes and yet am having them again. I think doctors should emphasize this possibility and not rely on the patient reading page after page of "small print". Elise