There are no clinical studies on Serenity and bipolar disorder. For example, what happens if an individual takes several Serenity pills? Does Serenity interact with other drugs or herbs, or can one overdose with Serenity? Answers to these questions remain unknown.

The problem with conventional lithium orotate is that it is a difficult drug to administer. Even the slightest changes in dose can either make the drug toxic or ineffective. So what happens if one combines the traditional lithium pill with Serenity - will there be more side effects? Again, the answer to this question is unknown.

To date, there is very little information on Serenity. Is there evidence that lithium orotate (Serenity) even works?

None. There are no clinical studies on this supplement. There are some positive testimonials from individuals who have taken Serenity, but there are a lot of negative testimonials about the supplement also. For the most part, consumers claim Serenity does diddly squat and is a waste of money. Moreover, there is evidence that the product quality and quantity of lithium orotate does vary from store to store and even among the same brand.

So what about the consumer?

For those who decide to take Serenity, start at the lowest dose. The supplement has been deemed safe when it is taken alone. The starting dose is about 150 to 200 mg/day. However, if you are already taking other medications for your depression or bipolar disorder, it is wise to discuss the issue with your physician before embarking on a complex hodgepodge of drugs.

A month’s supply of Serenity can cost anywhere from $20 to $40. Remember, many such herbal supplements are made in India and China, where unscrupulous manufacturers have sometimes added the actual drug inside the supplement. Further, dangerous contaminants in herbal products are not unheard of. Fakes and counterfeits are also abundant in the health supplement market. So in the end, the caveat “buyer beware” should be well-heeded.